Doggett attempts to uncover the truth about a woman with superhuman abilities who is somehow connected to scientific experiments being conducted in a lab aboard a secret ship that stays at sea year round.
A professor/inmate in a psychiatric ward may be influencing other men to kill ritualistically. Though Doggett sees it as pure manipulation, Reyes can't help but suspect none else but the devil himself possessing the professor's body.
Agent Dogget has been shot and hospitalized. The only suspect is his partner. However, she was 14 miles away when the shooting occurred. The team sticks together to solve the case of being in two places at one time.
A man is chased from the Canada/US border and reportedly burned alive though his body is not found. Meanwhile, in the burned remains, the FBI finds papers with the same UFO markings Scully found in Africa.
Reyes is seriously injured in a car accident and finds herself in a hospital similar to purgatory with other hospital patients suffering from serious traumas. Slowly they all begin to disappear. Meanwhile, in the real world, Doggett refuses to accept his friend's 'mortal' wounds and uses a bizarre hospital employee to both connect with Reyes in the other-world and capture a 'Dr. Death.'
After thirteen years in prison, a man named Fassl is released and cleared of murder charges when DNA evidence proves he had nothing to do with the murder of an entire family though he was present on the scene. Doggett, who made the arrest, refuses to accept Fassl's innocence and pursues the case again.