When a police captain's son is arrested in a drug sweep, Eliot Ness decides to try and locate the source of the drugs. The pusher was someone known as Peepers but he dies before they can get much information from him. They do manage to trace him to Chicago nightclub owner Sal Rudin and believe the heroin originated in New Orleans. Ness travels to the Big Easy posing as a bass player and meets booking agent Russ Bogan, who is part of the distribution network. He also learns of their unique system of delivering the goods across the country.