The Daily Bugle logo can be seen on buildings and mostly on buses.
Glenn Talbot appears in this game and plays an active role in the hunt for Hulk, and is killed when his Hulkbuster armor detonates. He has appeared in several episodes of the first, second, third, fourth and fifth seasons of Agents of S.H.I.E.L.D. and is killed in the Battle of Chicago when Quake launches him into space.
The publishing facility of The Daily Bugle appears in this game as one of the game's various landmarks, depicted as a tabloid newspaper like in the comics. In Spider-Man: Far From Home, The Daily Bugle is depicted as web news media outlet.
Rick Jones appears in this game where he meets Bruce Banner for the first time and they become allies. In The Incredible Hulk, Rick Jones is mentioned on the United States Armed Forces' file on Banner, where it states that he met Banner at Culver University before he became Hulk.
Bi-Beast appears in this game as an android created by the Enclave. In Thor: Ragnarok, Bi-Beast is featured among the sculptures of Sakaar, indicating that he is one of the former Champions of the Grandmaster's Contest of Champions.
Banner arrives in New York City very early in this game and most of the action takes place there. In the film the game is based on, Banner only reaches New York towards the end, having spent most of the film on the run.
Stark Tower appears in this game. In The Avengers, the tower has only just completed construction. The MetLife Building also appears in the game, despite being the basis for Stark Tower.
The Nelson and Murdock Law Office appears in the game. In Daredevil, Matt Murdock and Foggy Nelson have only just set up their law firm and bought the office at the beginning of the series.
The Baxter building also makes an appearance in the game.